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Ciprofloxacin syrup 250 mg/mL Powder (1 oz) 12.5 µg/mL (0.2 mg/mL) (Bacteriostatic) (Dosing recommended for infants in NICU, older children, and pregnant women in NICU) 0.8 mg/kg/infant (5 kg) 1 mg/kg/infant (40 kg) 5 mg/mEq/kg/child (100 kg) 0.75 mg/kg/child 2 mg/kg/child (100kg) 1 mg/kg/child(25 kg) 0.2 mg/kg/child (25kg) *NOTE: In clinical studies of ciprofloxacin ointment application 500 mg/l for 30 hours a total of 400 mg/kg ointment was absorbed by the system, bioavailability of drug was 70%. In vitro studies were inconclusive. NOTE: In the clinical study of ciprofloxacin ointment application with 1.0 mg/kg for 5 hours a total of 8.5 mg/kg ointment was absorbed by the system, drug bioavailability was 70%. The could be increased to 100% following the application of drug with a dose 2.5 g/kg/day in neonates. *NOTE: In the clinical trial of ciprofloxacin ointment application with 1.0 mg/kg for 6 hours a total of 13.2 mg/kg ointment was absorbed by the patient, drug bioavailability was 70% and the could be increased to 140% by application of 2.5 g/kg/day for 1 week in neonates. *NOTE: In the clinical study of ciprofloxacin ointment application with 1.0 mg/kg for 10 hours a total of 22.5 mg/kg ointment was absorbed by the patient, drug bioavailability was 70% and the could be increased to 100% by application of 2.5 g/kg/day for 2 weeks in neonates. *NOTE: In trials of ciprofloxacin ointment application with 1.0 mg/kg 1 g on a daily basis for 1 week in neonates a total of 42.5 mg was absorbed by children, which significantly lower than the maximum absorption achieved by drug with a maximum dose of 1 g/day. *NOTE: Although it has been reported that the bioavailability for both topical ointment and injection of american online pharmacy with prescription ciprofloxacin is very low when used at recommended dosage with standard dosages and routes of administration, the authors consider that it will not be unlikely, as is the case for many other antimicrobials in the market, that drug's mechanism of action will affect the systemic bioavailability in absence of specific drug-drug interactions with the drug. References: Clinical Pharmacology Reviews, Vol 15, No 4, pp 509 - 519. JAMA, 1987: Vol. 264, No. 20, pp. 1285 – 1292. S.A. Zia-Zamani, S.M. Kausik, P.C. Rastogi. Effect of ciprofloxacin upon skin permeability through nonpermeable and permissive materials: in vitro evaluation. Phlebologia, 1979, 16, No 1: pp 495 – 497. Clinical Pharmacology Reviews, Vol 9, No 8, pp 391 – 403. J Clin Pharmacol, 1979: Vol 33, No 9, pp 717 – 723. Clin Drug Ther, 1978, 16 (8), p 717 – 723, 5 pp 549 550. J Pharm Sci, 1979, 73 (6), pp 1036 – 1037. J Pharm Sci, 1980, 75 (8), pp 743 – 745. J Clin Pharm Ther, 1978, 49 (3), pp 663 – 664. J Clin Pharm Ther, 1976, 40 (9), pp 1125 – 1131. Bacterial Food Biology, 1979, 13 (8), pp 393 – 402. Clin J Pharm Sci, 1980, 74 (8), pp 673 – 674. J Pharm Sci, 1977, 58 (9), pp 2187 – 2195. Clin Drug Ther, 1978, 56 (3), pp 543-549.

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