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Sulfatrim dose pediatric ians should administer (0.25%-0.5% sodium sulfadiazine for oral or intravascular administration) to children ≥2 years of age at a dose 0.5% per kilogram of body weight (0.05%-0.6% for intravascular administration). (See DRUG INTERACTIONS under Cautions.) Drugs and Antibiotics (Non-Steroidal) The safety of using antibiotics and nonsteroidal anti-inflammatory drugs (NSAIDs) in children has not been evaluated. Adults The safety of using drugs and medications in adults has not been systematically evaluated. Information regarding drug interactions with the following drugs is NOT available. Buprenorphine Buprenorphine is contraindicated in patients who are HIV-negative, have a history of substance abuse, and/or have liver disease. It is not known whether buprenorphine exposure is related to the increased risk of drug-related deaths associated with treatment-resistant opiate addiction. Cannabis Cannabis use can result in the conversion of naloxone to morphine. These changes in naloxone levels may increase the risk of respiratory depression when naloxone is administered. Patients who are not opioid naive may be at an increased risk for respiratory depression when naloxone is administered. Chlorpromazine Chlorpromazine is contraindicated in patients with known cardiovascular disease, and it is not known whether drug interactions with chlorpromazine are related to the risk of death associated with treatment-resistant opiate addiction or to the risk of cardiac arrhythmias. use chlorpromazine in patients with a history of cardiovascular disease and/or who are taking other drugs that can result in arrhythmias may increase the risk of cardiac arrhythmias. Clonazepam Clonazepam is contraindicated in patients with a history of cardiac disease, and the use of clonazepam may increase the risk of cardiovascular death. Chlorthalidone Ciprofloxacin should not be given to patients who have received a prior course of carbamazepine that includes a total Tramadol uk pharmacy of more canada drug pharmacy free shipping code than 100 mg levofloxacin, or to patients who are being treated with levofloxacin. Cisapride Cisapride is contraindicated in patients weighing >250 kg and in those patients with severe hepatic impairment. Contraindicated in patients with liver disease [see ADVERSE REACTIONS]. Corticosteroids Corticosteroids should be used with caution in patients known predisposing diseases [see ADVERSE REACTIONS]. The recommended dosage for most adult patients has been set based on an estimate of the maximum dose that has been shown to reduce the risk for sudden death in patients with severe acute respiratory distress syndrome [see DOSAGE AND ADMINISTRATION]. The recommended concentration of corticosteroids in pediatric doses 2 mg/kg/day, for children weighing <2 kg and in children weighing >2 kg that have severe acute respiratory distress syndrome, has been set based on the most recent literature available on this issue. The recommended dosage of prednisone in adult patients has been set based on an estimate of the maximum dose that has been shown to reduce the risk for sudden death in patients with severe acute respiratory distress syndrome [see Dosage and Administration]. Contraindications Hypersensitivity Reactions to Medication In clinical trials, approximately 30% to 50% of patients received a dose prednisone greater than or equal to the recommended dose or a that was not well tolerated (dose titration was not possible in these trials due to the small number of patients with adverse reactions to prednisone). Based on the experience with corticosteroids and prednisone the following reactions to are most frequently reported: Agranulocytosis. Carpal tunnel syndrome. Central nervous system (CNS) depression, including transient coma, and death. Dizziness. Headache. Hypertension. Muscle spasm. Pituitary adenomas. Sudden Death. Tachycardia. Tremor. Ulceration of the tonsils and adenoids adenocarcinoma in the tonsils. Hypersensitive Reactions Associated With Other Medications If hypersensitivity to a particular medication is suspected, prednisone can be adjusted upward or downward in its recommended dose [see DRUG INTERACTIONS]. Other Drugs and Medications Not listed in Table 1
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